Product Name :
PAK1 Recombinant Rabbit Monoclonal Antibody [JE57-36]
Predicted band size :
Observed band size :
Synonyms:
Alpha PAK antibody Alpha-PAK antibody MGC130000 antibody MGC130001 antibody p21 activated kinase 1 antibody p21 protein (Cdc42/Rac) activated kinase 1 antibody p21-activated kinase 1 antibody p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related) antibody p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) antibody p65 PAK antibody 展开
Function :
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway.760952-88-3 site This specific family member regulates cell motility and morphology.147969-86-6 In stock Alternatively spliced transcript variants encoding different isoforms have been found for this gene.PMID:33740186
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within human PAK1 aa 1-50.
Species reactivity:
Human, Mouse, Rat, Rat
Verify application:
WB, IF-Cell, IHC-P, FC
Coupling :
unconjugated
Clone number:
JE57-36
RRID:
AB_3071090
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
61 kDa
Positive control :
HL-60 cell lysates, F9, human lung carcinoma tissue, human stomach carcinoma tissue, mouse brain tissue.