Product Name :
SIRT1 Rabbit Polyclonal Antibody
Predicted band size :
82 kDa
Observed band size :
110 kDa
Synonyms:
75SirT1 antibody hSIR2 antibody hSIRT1 antibody HST2, S. cerevisiae, homolog of antibody NAD dependent deacetylase sirtuin 1 antibody NAD dependent protein deacetylase sirtuin 1 antibody OTTHUMP00000198111 antibody OTTHUMP00000198112 antibody Regulatory protein SIR2 homolog 1 antibody SIR1_HUMAN antibody 展开
Function :
SirT1, the mammalian ortholog of Sir2, is a nuclear protein implicated in the regulation of many cellular processes, including apoptosis, cellular senescence, endocrine signaling, glucose homeostasis, aging, and longevity. Targets of SirT1 include acetylated p53, p300, Ku70, forkhead (FoxO) transcription factors, PPARγ, and the PPARγ coactivator-1α (PGC-1α) protein. Deacetylation of p53 and FoxO transcription factors represses apoptosis and increases cell survival. SirT1 deacetylase activity is inhibited by nicotinamide and activated by resveratrol.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide within Human SIRT1 aa 698-747 / 747.
Species reactivity:
Human, Mouse
Verify application:
WB, IHC-P, FC, IF-Cell
Coupling :
unconjugated
Clone number:
RRID:
AB_3069022
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.1011460-68-6 Chemscene Aliquot store at -20℃ or -80℃.1309377-79-4 site Avoid repeated freeze / thaw cycles.PMID:33710424
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 82 kDa
Positive control :
Hela cell lysate, Jurkat cell lysate, F9 cell lysate, HeLa, F9, human colon carcinoma tissue, human lung carcinoma tissue, mouse liver tissue, mouse testis tissue.