Product Name :
SHC Recombinant Rabbit Monoclonal Antibody [JE57-45]
Predicted band size :
63 kDa
Observed band size :
66/52/46 kDa
Synonyms:
FLJ26504 antibody p66 antibody p66SHC antibody SH2 domain protein C1 antibody SHC (Src homology 2 domain containing) transforming protein 1 antibody SHC 1 antibody SHC A antibody SHC adaptor protein 1 antibody Shc antibody SHC transforming protein 1 antibody 展开
Function :
Overexpression of SHC proteins are associated with cancer mitogenesis, carcinogenesis and metastasis. The SHC and its adaptor proteins transmit signaling of the cell surface receptors such as EGFR, erbV-2 and insulin receptors. p52SHC and p46SHC activate the Ras-ERK pathway. p66SHC inhibits ERK1/2 activity and antagonize mitogenic and survival abilities of T-lymphoma Jurkat cell lines. A rise in p66SHC promotes stress induced apoptosis. p66SHC functionally is also involved in regulating oxidative and stress- induced apoptosis – mediating steroid action through the redox signaling pathway. P52SHC and p66SHC have been found in steroid hormone-regulated cancer and metastasizes.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
JE57-45
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.(S)-3-Phenylmorpholine manufacturer Aliquot store at -20℃.Formula of 2-Amino-3-iodopyridine Avoid repeated freeze / thaw cycles.PMID:33560890
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 63 kDa
Positive control :
Jurkat cell lysate, HepG2 cell lysate, A431 cell lysate, HeLa cell lysate, NIH/3T3 cell lysate, RAW264.7 cell lysate, C6 cell lysate, human lung cancer tissue.