Product Name :
STAT1 Mouse Monoclonal Antibody [G3-B11]
Predicted band size :
87/83 kDa
Observed band size :
87/83 kDa
Synonyms:
Signal transducer and activator of transcription 1 91kD antibody CANDF7 antibody DKFZp686B04100 antibody IMD31A antibody IMD31B antibody IMD31C antibody ISGF 3 antibody ISGF-3 antibody OTTHUMP00000163552 antibody OTTHUMP00000165046 antibody 展开
Function :
STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Recombinant protein within Human STAT1 aa 71-270 / 750.1075198-30-9 site
Species reactivity:
Human
Verify application:
WB, IF-Cell, IHC-P
Coupling :
unconjugated
Clone number:
G3-B11
RRID:
AB_3073085
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
Store at +4℃ after thawing.[2,2′-Bipyridine]-5,5′-diamine custom synthesis Aliquot store at -20℃ or -80℃.PMID:33586576 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG2b
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 87/83 kDa
Positive control :
Jurkat cell lysate, A431 cell lysate, HeLa cell lysate, A549 cell lysate, SK-Br-3 cell lysate, SK-MEL-28 cell lysate, MCF7 cell lysate, HT-29 cell lysate, HT-29, human breast cancer tissue, human spleen tissue.