Product Name :
Smad2/3 Mouse Monoclonal Antibody [4D3]
Predicted band size :
Observed band size :
Synonyms:
Drosophila homolog of MADR2 antibody hMAD-2 antibody HsMAD2 antibody JV18 antibody JV18-1 antibody JV181 antibody MAD antibody MAD homolog 2 antibody 展开
Function :
Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and Activin-mediated growth modulation.2-Chloro-5-nitropyrazine manufacturer Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members.Bicyclo[2.2.1]Hept-5-en-2-one Data Sheet Smad6 and Smad7 regulate the response to Activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad proteins.PMID:33517414
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
peptide
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IP, IF, IHC-P
Coupling :
unconjugated
Clone number:
4D3
RRID:
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
Store at +4℃
Storage buffer solution:
1.0 ml of PBS with
Subtype:
IgG1
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
55-60kDa
Positive control :
human thyroid tissue.