Product Name :
hnRNP Q Recombinant Rabbit Monoclonal Antibody [JG35-72]
Predicted band size :
70 kDa
Observed band size :
70 kDa
Synonyms:
cytoplasmic RNA-interacting protein antibody dJ3J17.2 antibody Glycine and tyrosine rich RNA binding protein antibody Glycine- and tyrosine-rich RNA-binding protein antibody GRY RBP antibody GRY-RBP antibody GRYRBP antibody Heterogeneous nuclear ribonucleoprotein Q antibody hnRNP Q antibody HNRPQ antibody 展开
Function :
Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regulated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN results in spinal muscular atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregulated after midnight, and this upregulation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regulation of circadian oscillation.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human hnRNP Q aa 574-623 / 623.
Species reactivity:
Human, Rat, Mouse
Verify application:
WB, IHC-P, IF-Cell, IF-Tissue
Coupling :
unconjugated
Clone number:
JG35-72
RRID:
AB_3070817
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.2′,3′-Dideoxy-5-iodouridine Purity Aliquot store at -20℃.Formula of 3-Hydroxy-1-methylazetidine Avoid repeated freeze / thaw cycles.PMID:33547597
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 70 kDa
Positive control :
K562 cell lysates, rat brain tissue lysates, LOVO, SiHa, rat testis tissue, human thyroid tissue, human breast tissue, human kidney tissue.