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Gilpin et al. BMC Pulmonary Medicine 2013, 13:48 http://biomedcentral/1471-2466/13/RESEARCH ARTICLEOpen AccessBone marrow-derived progenitor cells in end-stage lung condition patientsSarah E Gilpin1, Kalvin Lung1, Geoffrey T de Couto2, Marcelo Cypel1, Masaaki Sato1, Lianne G Singer1, Shaf Keshavjee1 and Thomas K Waddell1*AbstractBackground: Persistent lung illnesses are marked by progressive irritation, tissue damage and remodelling. Bone marrow-derived progenitor cells may well contribute to these processes. The goals of this examine had been to (1) to quantify CD45+Collagen-1+ fibrocytes along with a novel epithelial-like population of bone marrow-derived cells, which express Clara Cell Secretory Protein, in patients at the time of lung transplant and (2) to assess mediators that could act to recruit these cells during damage. Techniques: Using an observational layout, progenitor cells were quantified by flow cytometry from the two bone marrow (BM) and peripheral blood (PB). Migration was examined using in vitro transwell assays. Multiplex bead-based assays were used to quantify plasma cytokines. Benefits: An increase in CD45+Collagen-1+ fibrocytes was observed in pulmonary fibrosis and bronchiolitis obliterans sufferers. Cystic fibrosis patients had a rise in CCSP+ cells in each the BM and PB. The proportion of CCSP+ cells from the BM.