Product Name :
3-Hydroxy-3-methylglutaric Acid (CAS 503-49-1)
Synonym :
Meglutol
Application :
3-Hydroxy-3-methylglutaric Acid is An antilipemic agent
CAS:
503-49-1
Purity:
≥98%
Molecular Weight:
162.14
Formula :
C6H10O5
Physical state:
Solid
solubility :
Soluble in Acetone and Methanol
Shipping Condition :
Store at 4° C
Melting point:
97-99° C
SMILES:
CC(CC(=O)O)(CC(=O)O)O
References:
:The urinary organic acid profile associated with 3-hydroxy-3-methylglutaric aciduria.101-98-4 Synonym | Faull, KF., et al. 1976. Clin Chim Acta. 73: 553-9. PMID: 10008723-Hydroxy-3-methylglutaric aciduria in an Italian patient is caused by a new nonsense mutation in the HMGCL gene. | Funghini, S., et al. 2001. Mol Genet Metab. 73: 268-75. PMID: 11461194Evidence that 3-hydroxy-3-methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex.1219454-89-3 SMILES | Leipnitz, G.PMID:33445993 , et al. 2008. J Neurosci Res. 86: 683-93. PMID: 17941049New C-2 diastereomers of flavanone glycosides conjugated with 3-hydroxy-3-methylglutaric acid from the pericarp of Citrus grandis (L.) Osbeck. | Ma, SG., et al. 2018. Bioorg Chem. 80: 519-524. PMID: 300052023-Hydroxy-3-Methylglutaric Acid Impairs Redox and Energy Homeostasis, Mitochondrial Dynamics, and Endoplasmic Reticulum-Mitochondria Crosstalk in Rat Brain. | da Rosa, MS., et al. 2020. Neurotox Res. 37: 314-325. PMID: 31721046Studies on the hypolipidemic and hypocholesterolemic effect of 3-hydroxy-3-methylglutaric acid in rabbits. | Yusufi, AN. and Siddiqi, M. 1974. Atherosclerosis. 20: 517-26. PMID: 44296203-Hydroxy-3-methylglutaric acid: protective action in experimental atherosclerosis in rabbits. | Lupien, PJ., et al. 1973. Atherosclerosis. 18: 407-16. PMID: 4751225In vitro and in vivo inhibition of hepatic cholesterol synthesis by 3-hydroxy-3-methylglutaric acid. | Beg, ZH. and Lupien, PJ. 1972. Biochim Biophys Acta. 260: 439-48. PMID: 5061662Effect of 3-hydroxy-3-methylglutaric acid on blood lipids in normal and cholesterol-fed rats. | Beg, ZH. and Siddiqi, M. 1968. Experientia. 24: 791-2. PMID: 56831673-Hydroxy-3-methylglutaric acid (HMGA) reduces dietary cholesterol induction of saturated bile in hamster. | Di Padova, C., et al. 1982. Life Sci. 30: 1907-14. PMID: 6180274Molecular prenatal diagnosis of 3-hydroxy-3-methylglutaryl CoA lyase deficiency. | Mitchell, GA., et al. 1995. Prenat Diagn. 15: 725-9. PMID: 7479590Identification of 3-hydroxy-3-methylglutaric acid (HMG) as a hypoglycemic principle of Spanish moss (Tillandsia usneoides). | Witherup, KM., et al. 1995. J Nat Prod. 58: 1285-90. PMID: 7595594Combined 3-methylglutaconic and 3-hydroxy-3-methylglutaric aciduria with endocardial fibroelastosis and dilatative cardiomyopathy in male and female siblings with partial deficiency of complex II/III in fibroblasts. | Ruesch, S., et al. 1996. Enzyme Protein. 49: 321-9. PMID: 92527903-Hydroxy-3-methylglutaric aciduria, combined with 3-methylglutaconic aciduria. | Wysocki, SJ., et al. 1976. Clin Chim Acta. 70: 399-406. PMID: 9476333-hydroxy-3-methylglutaric acid and experimental atherosclerosis in rats. | Yousufzai, SY. and Siddiqi, M. 1976. Experientia. 32: 1033-4. PMID: 955013